rb protein การใช้

Rb protein also can block the uncontrolled cell division that is cancer's hallmark _ and thus solid tumors lack properly functioning Rb.
Its E1A gene makes a substance that disrupts the Rb protein, while E1B-55K blocks the division-arrest function of p53, and E1B-19K jams p53's cell-suicide program.
All cancer cells must therefore knock out their Rb protein, either directly or indirectly, by acquiring mutations in the Rb gene itself or the genes that control it.
Onyx-411 is an adenovirus engineered to grow only in the presence of a protein called E2F . This protein is directly inhibited by Rb and is found in high levels only in cancer cells that have sabotaged their Rb protein.
But a highly ingenious way of targeting cancer cells through their inactivated tumor suppressor genes has been devised by McCormick of U . C .-San Francisco and is being developed by a company he founded, Onyx Pharmaceuticals of Richmond, Calif . The agents are genetically altered viruses that will grow only in cells that have inactivated their p53 or Rb proteins.